Author/Editor		Wensing, Barbara; Relvas, Lia M; Caspers, Laure E; Vidovič-Valentinčič, Nataša; Štunf, Špela; de Groot-Mijnes, Jolanda DF; Rothova, Aniki
Title		Comparison of rubella virus- and herpes virus-associated anterior uveitis: clinical manifestations and visual prognosis
Type		članek
Source		Ophthalmology
Vol. and No.		Letnik 118, št. 10
Publication year		2011
Volume		str. 1905-10
Language		eng
Abstract		Purpose: To compare the clinical characteristics and visual prognosis of patients with anterior uveitis (AU) and intraocular fluid analysis positive for rubella virus (RV), herpes simplex virus (HSV), or varicella zoster virus (VZV). DESIGN: Retrospective, observational study. Participants: The study included 106 patients with AU and positive polymerase chain reaction (PCR) results, Goldmann-Witmer coefficients (GWCs), or both, for RV (n = 57), HSV (n = 39), or VZV (n = 10). Mezhods: Clinical records of the included patients were analyzed retrospectively; demographic constitution, ophthalmologic characteristics, and visual prognosis were compared. Main outcome measures: Age, gender, and diverse clinical and laboratory characteristics, including course and laterality of AU; prevalence of positive results for PCR, GWC, or both; conjunctival redness; corneal edema; history of keratitis; presence of keratic precipitates; synechiae; heterochromia; and grade of inflammation. In addition, complications and visual acuity at 1 and 3 years of follow-up were recorded. Results: All 3 types of viral AU were characterized by unilateral involvement (80%-97%). Rubella virus AU was characterized by younger age at onset and chronic course and typically was associated with cataract at presentation. Heterochromia was present in 23% of RV AU patients. Anterior uveitis associated with HSV or VZV occurred characteristically in older patients and frequently followed an acute course. Clinical features associated with herpetic AU included conjunctival redness, corneal edema, history of keratitis, and development of posterior synechiae. Herpes simplex virus AU often had severe anterior chamber inflammation, whereas the presence of vitritis was more common in RV AU and VZV AU. The prevalence of documented intraocular pressure (IOP) of more than 30 mmHg (25%-50%; P = 0.06) and development of glaucoma (18%-30%; P = 0.686) were similar in all 3 groups. (Abs. trunc. at 2000 ch.)
Descriptors		ADULT AGED AGED, 80 AND OVER AQUEOUS HUMOR CHILD DNA, VIRAL EYE INFECTIONS, VIRAL GENOME, VIRAL HERPES SIMPLEX HERPES ZOSTER OPHTHALMICUS HERPESVIRUS 1, HUMAN HERPESVIRUS 3, HUMAN INTRAOCULAR PRESSURE POLYMERASE CHAIN REACTION PROGNOSIS RETROSPECTIVE STUDIES RUBELLA RUBELLA VIRUS UVEITIS, ANTERIOR VISUAL ACUITY