Author/Editor     Perko, Denis; Zaletel, Marjan
Title     Preventiva ishemične možganske kapi s protitrombotičnimi zdravili
Translated title     The prevention of ischemic stroke with antithrombotic drugs
Type     članek
Source     Zdrav Vestn
Vol. and No.     Letnik 81, št. 2
Publication year     2012
Volume     str. 128-38
ISSN     1318-0347
Language     slo
Abstract     Current antithrombotic drugs reduce the risk of stroke, heart attack and death from vascular causes by 25 % in patients with cerebral ischemic events resulting from disease of small or large cerebral arteries. In the primary prevention, Acetylsalicylic acid (ASA) reduces the risk of stroke by 19 % in women but not in men. In patients with nonvalvular atrial fibrillation the risk of stroke treating with ASA is reduced by 20 %. Oral anticoagulants significantly reduce stroke risk due to nonvalvular atrial fibrillation by 65-70 % compared with placebo and by 40% compared with ASA alone. At the same time they cause more major bleedings. Recently studied new antiplatelet drugs and anticoagulants might alter the current course of stroke prevention treatment. Research is also needed on the benefits and risks of combination antiplatelets and anticoagulants in patients with nonvalvular atrial fibrillation in combination with arterial cerebral disease.
Descriptors     CEREBRAL ISCHEMIA
CEREBRAL INFARCTION
PLATELET AGGREGATION INHIBITORS
ASPIRIN
ATRIAL FIBRILLATION
ANTICOAGULANTS