Author/Editor | Miller, Christopher M; Rindflesch, Thomas C; Fiszman, Marcelo; Hristovski, Dimitar; Shin, Dongwook; Rosemblat, Graciela; Zhang, Han; Strohl, Kingman P | |
Title | A closed literature-based discovery technique finds a mechanistic link between hypogonadism and diminished sleep quality in aging men | |
Type | članek | |
Source | Sleep | |
Vol. and No. | Letnik 35, št. 2 | |
Publication year | 2012 | |
Volume | str. 279-85 | |
Language | eng | |
Abstract | STUDY OBJECTIVES: Sleep quality commonly diminishes with age, and, further, aging men often exhibit a wider range of sleep pathologies than women. We used a freely available, web-based discovery technique (Semantic MEDLINE) supported by semantic relationships to automatically extract information from MEDLINE titles and abstracts. DESIGN: We assumed that testosterone is associated with sleep (the A-C relationship in the paradigm) and looked for a mechanism to explain this association (B explanatory link) as a potential or partial mechanism underpinning the etiology of eroded sleep quality in aging men. MEASUREMENTS AND RESULTS: Review of full-text papers in critical nodes discovered in this manner resulted in the proposal that testosterone enhances sleep by inhibiting cortisol. Using this discovery method, we posit, and could confirm as a novel hypothesis, cortisol as part of a mechanistic link elucidating the observed correlation between decreased testosterone in aging men and diminished sleep quality. CONCLUSIONS: This approach is publically available and useful not only in this manner but also to generate from the literature alternative explanatory models for observed experimental results. | |
Descriptors | HYPOGONADISM SLEEP DISORDERS AGING TESTOSTERONE INFORMATION STORAGE AND RETRIEVAL CORTISONE MEDLINE |