| Author/Editor | Vrabec, Matej; Van Cauter, Sofie; Himmelreich, Uwe; Van Gool, Stefaan W; Sunaert, Stefan; De Vleeschouwer, Steven; Šuput, Dušan; Demaerel, Philippe | |
| Title | MR perfusion and diffusion imaging in the follow-up of recurrent glioblastoma treated with dendritic cell immunotherapy: a pilot study | |
| Type | članek | |
| Source | Neuroradiology | |
| Vol. and No. | Letnik 53, št. 10 | |
| Publication year | 2011 | |
| Volume | str. 721-31 | |
| Language | eng | |
| Abstract | Introduction: This study aims to determine the potential value of MR-PWI and MR-DWI to differentiate immune therapy-induced inflammatory response from recurrent glioblastoma tumour growth. Both can present as contrast-enhancing lesions on conventional magnetic resonance imaging (MRI). Methods: Patients with recurrent glioblastoma who could obtain a total or near-total resection were treated with dendritic cell immune therapy according to the HGG-IMMUNO-2003 trial. A retrospective analysis of 32 follow-up MRI examinations (mean follow-up time 21 months) in eight patients was performed for this pilot study. For the statistical analysis, the 32 examinations were divided into three groups: 0-obtained in patients that remained stable during the follow-up period, 1a-obtained in progressive-tumour patients at time points before definite progression and 1b-obtained in patients at or after progression. Results: Maximum lesional rCBV ratios were highest in group 1b (Student t test, 9.25 +/- 2.68; p < 0.001) and were higher in group 1a (4.87 +/- 1.61, p < 0.001) compared to group 0 (1.22 +/- 0.47). The minimum apparent diffusion coefficients (ADCs) in the contrast-enhancing regions were lower in group 1a (0.62 +/- 0.06 x 10(-3) mm(2)/s) than in group 0 (1.03 +/- 0.43 x 10(-3) mm(2)/s, p = 0.01) and higher in group 1b (0.76 +/- 0.08) compared to 1a (p = 0.02). The minimum ADCs in the FLAIR-hyperintense region were lower in group 1a (0.62 +/- 0.06, p = 0.02) compared to group 0 (0.76 +/- 0.16) but not significantly different in group 1b (0.68 +/- 0.07) from groups 0 and 1a (p = 0.33, p = 0.10). The mean ADCs of the FLAIR-hyperintense region and the mean ADCs of the contrast-enhancing lesion were not significantly different. (Abs. trunc. at 2000 ch.) | |
| Descriptors | DENDRITIC CELLS ADULT BRAIN BRAIN NEOPLASMS CONTRAST MEDIA FOLLOW-UP STUDIES GLIOBLASTOMA IMAGE ENHANCEMENT IMMUNOTHERAPY PERFUSION PILOT PROJECTS TREATMENT OUTCOME |