Author/Editor		Pintar, Tadeja; Alessiani, Mario; Pleskovič, Alojz; Pleskovič, Aleš; Zorc-Pleskovič, Ruda; Milutinović, Aleksandra
Title		Skin and kidney histological changes in graftversus-host disease after kidney transplantation
Type		članek
Source		Bosnian journal of basic medical sciences
Vol. and No.		Letnik 11, št. 2
Publication year		2011
Volume		str. 119-23
Language		eng
Abstract		Kidney transplantation (Ktx) is generally performed during end stage renal disease due to a loss of the kidneys' ability to fi lter wastes from the circulatory system. Acute graft-versus-host disease (GVHD) after Ktx is a life-threatening complication that progresses to organ failure, systemic complications, and death. The current study evaluated the signifi cance of histologic fi ndings of GVHD as obtained from skin biopsies following Ktx in swine. A swine model of Ktx with tacrolimus-based immunosuppression was used to assess possible correlations between acute-graft-cellular rejection and skin histological fi ndings for prediction of GVHD. Animals were divided into a Ktx treatment group or a control group with no Ktx and skin and kidney biopsies were histologically assessed at postoperative days 0, 15, 30, 45 and 60. Skin samples were analyzed and classified from grade 1 to 4 of skin GVHD and the major histopathological changes of kidney acute cellular rejection were described using Banff's score system. We observed a signifi cant linear correlation between the histological grading values of skin biopsy changes and the histological grading values of kidney biopsies (Kendall's tau_b=0,993 in the Ktx experimental group. No histological changes were observed in controls. Our fi ndings demonstrate the diagnostic value of staging skin GVHD after Ktx and suggest it's future utility for monitoring long term Ktx-induced changes.
Descriptors		KIDNEY TRANSPLANTATION GRAFT VS HOST DISEASE SKIN MANIFESTATIONS BIOPSY KIDNEY DISEASES GRAFT REJECTION TACROLIMUS DISEASE MODELS, ANIMAL SWINE