Author/Editor     Pavlović, Miloš D; Adamič, Metka
Title     Oralni propranolol u lečenju visokorizičnih hemangioma odojčadi
Translated title     Oral propranolol in the treatment of high-risk infantile hemangiomas
Type     članek
Source     Pedijatrija danas
Vol. and No.     Letnik 7, št. 1
Publication year     2011
Volume     str. 1-5
Language     ser
Abstract     Hemangiomas are the most common tumor s of the infancy. Early growth phase after birth is succeeded bya slow spontaneous involu60n. This biologic behavior means that most hemangiomas should not be treated. Yet, in case of ulcerated hernangiomas as well as tumors at special sites (periorbital, oropharyngeal, preauricular or parotid regions), prompt and ac6ve treatment is warranted in order to avoid serious complicat.ions. Un61 recently, drugs of choi ce for such hemanf,riomas were systemic corticosteroids. Over the past 3 years there bas been a growing body of literature about successful and safe use of oral propranolol in the treatment of infanwe hemangiomas. Propranolol (at an average daily dose of 2 mg/kg) now seems to be a first-line rnedication for high-risk and ulcerated infantile hemangiornas. With a proper patient selection and monitoring of effects and si de-effects (hypoglycernia, hypotension, bradycardia, bronchoconstriction), its efficacy overrides tl1e efficacy of cort.icosteroids with an excellent safety profile.