Author/Editor     Košnik, M
Title     Dinamika aktivnosti limfocita pri hiposenzibilizaciji na pčelinji otrov
Type     monografija
Place     Zagreb
Publisher     Medicinski fakultet Sveučilišta u Zagrebu
Publication year     1993
Volume     str. 67
Language     cro
Abstract     Hyposensibilization is a successful method for the treatment of several allergic diseases, yet the mechanisms leading to immune tolerance have not been clarified. On the sample of hypersensitivity for bee venom the course of both humoral and cell immunity have been studied during the rush desensitisation for bee venom. The group of patients with systemic hypersensitivity reaction to bee venom (n=17) has been compared with the group of healthy subjects (n=9). The group of patients had statistically significant higher concentration of total (clgE) and bee venom specific IgE (slgE), specific blocking IgG (slgG) as well as higher skin reactivity for bee venom. There was no significant difference between the groups as to the concentration of lymphocytes and their subpopulations in venous blood and the proliferative response of lymphocytes after stimulation with bee venom. In 14 patients the same parameters were compared prior and following the rush phase of hyposensibilization when the patients had already been tolerating the dosis of 100 micro g of bee venom. During this time there was a decrease in the specific skin reactivity and proliferation of lymphocytes after the stimulation with phorbol-myristat-acetate (PMA); the concentration of clgE, slgG and specific IgG4 antibodies (slgG4) has been increased. The concentration of slgE, lymphocytes and subpopulations of lymphocytes as well as the proliferation of lymphocytes after the stimulation with phytohemagglutinin (PHA) have not been changed. In 5 patients who had been followed up for 6 months, we found that the concentration of slgG began to decrease. According to these results we suppose that the tolerance for bee venom has been maintained by different meshanism and not by changes of concentrations of slgE and slgG.(trunc.)
Descriptors     HYPERSENSITIVITY
BEE VENOMS
DESENSITIZATION, IMMUNOLOGIC
SKIN TESTS
IGE
LYMPHOCYTES
LYMPHOCYTE TRANSFORMATION
IMMUNOLOGIC TESTS
IMMUNITY
IMMUNOCOMPETENCE