Author/Editor		Hudler, Petra
Title		Genetic aspects of gastric cancer instability
Type		članek
Source		The scientific world journal
Vol. and No.		Letnik 2012
Publication year		2012
Volume		str. 1-10, 761909
Language		eng
Abstract		Unravelling the molecular mechanisms underlying gastric carcinogenesis is one of the major challenges in cancer genomics. Gastric cancer is a very complex and heterogeneous disease, and although much has been learned about the different genetic changes that eventually lead to its development, the detailed mechanisms still remain unclear. Malignant transformation of gastric cells is the consequence of a multistep process involving different genetic and epigenetic changes in numerous genes in combination with host genetic background and environmental factors. The majority of gastric adenocarcinomas are characterized by genetic instability, either microsatellite instability (MSI) or chromosomal instability (CIN). It is believed that chromosome destabilizations occur early in tumour progression. This paper summarizes the most common genetic alterations leading to instability in sporadic gastric cancers and its consequences.
Descriptors		STOMACH NEOPLASMS ADENOCARCINOMA MICROSATELLITE REPEATS CHROMOSOME ABNORMALITIES DNA DAMAGE HELICOBACTER PYLORI SIGNAL TRANSDUCTION