Author/Editor		Hrastar-Kostešić, V
Title		Klamidijske infekcije pri moških na področju Pule
Type		monografija
Place		Pula
Publisher		Medicinska fakulteta
Publication year		1992
Volume		str. 48
Language		slo
Abstract		We studied the problem of nongonococcal (NGU) urethritis in men in Pula. We wonted to know the frequency of urethritis caused by Chlamydia trachomatis. Four tests were used for laboratoty diagnostic. We valuated all tests and established which one was the best for the detection of chlamydial infections in our population. We demonstrated to general practitioners novelties in laboratory diagnostic, complications after infections and the importance of the C. trachomatis in etiology of NGU. In a study of 162 men with NGU, C. trachomatis inclusion were sought in cycloheximide-treated McCoy cells, by the direct imunofluorescence (IF) antibody technique, the DNA hybridization and the indirect micro-IF for the detection of IgA and IgG antibodies in serum. We tested 111 asimptomatic men in control group. C. trachomatis antigen were detected by the direct-IF in the sediment of the first-void urine. C. trachomatis was isolated from 43 patients (25,5 per cent) with NGU and from 6 (5,4 per cent) man of the control group (p less th. 0,05). Results of the single test were compared with isolation in McCoy cells. The sensitivity of the direct IF and DNA hybridization were 87,5 per cent and 26,5 per cent, while the specificity were 97,5 per cent and 100 per cent. The positive (PPV) and negative (NPV) predictive values of direct IF were 92,1 per cent and 96 per cent, and of DNA-hybridization 100 per cent and 77 per cent. The sensitivities of the serological tests for IgA and IgG antibodies were low (40 per cent, 44 per cent), specificities satisfying (87,3 per cent, 95,8 per cent); positive p predictive values were 52,6 per cent and 78,5 per cent; negative predictive values were 80,7 per cent and 95,8 per cent). Patients with chlamydial urethritis were treated with tetracyclines or with macrolides. Samples collected at a control visit were positive in four patients. These patients were treated again and samples were negative.(trunc.)
Descriptors		CHLAMYDIA CHLAMYDIA INFECTIONS URETHRITIS CROATIA CHLAMYDIA INFECTIONS ANTIBIOTICS DIAGNOSIS, LABORATORY FLUORESCENT ANTIBODY TECHNIQUE