Author/Editor		Mavri, A
Title		Stalnost fibrinolitičnega odgovora na venski zažem pri zdravih
Translated title		Reproducibility of fibrinolytic response to venous occlusion in healthy volunteers
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 32, št. 3
Publication year		1993
Volume		str. 375-88
Language		slo
Abstract		Fibrinolytic response to venous occlusion is used to asses efficiency of fibrinolytic system. All factors that might influence fibrinolytic response are not known. The venous occlusion was performed twice within 12-23 days (=16 days) in 20 healthy volunteers. Fibrinolytic response was determined by euglobulin clot lysis time, by activity and antigen of tissue plasminogen activator (t-PA), by activity of t-PA inhibitors (PAI) and by antigen of endothelial t-PA inhibitor (PAI-1). The increases or decreases of measured parameters were calculated as a difference between values before and after stimulation. Comparing increases (decreases) after both venous occlusions, no statistically significant differences were determined in the whole group. However, quite big individual differences appeared in euglobulin clot lysis time increases, t-PA activity increases, and in PAI-1 antigen decreases. Statistically significant correlations between values after both venous occlusions were observed only for t-PA activity, PAI-1 antigen, and for t-PA activity increases and PAI activity decreases. Poor responders to venous occlusion were determined by five criteria. After the first venous occlusion 12 poor responses were observed (by all criteria together). After the second occlusion all poor responses, except one, changed to good responses, but nine other poor responses appeared. It was concluded that reproducibility of fibrinolytic response was poor in the observation period. Therefore, clinical significance of venous occlusion for assesing the effectiveness of fibrinolytic system is probably limited.
Descriptors		VEINS OCCLUSIVE DRESSINGS BLOOD COAGULATION TESTS FIBRINOLYSIS