Author/Editor | Loncar, Goran; von Haehling, Stepan; Tahirovic, Elvis; Inkrot, Simone; Mende, Meinhard; Sekularac, Nikola; Lainščak, Mitja | |
Title | Effect of beta blockade on natriuretic peptides and copeptin in elderly patients with heart failure and preserved or reduced ejection fraction: results from the CIBIS-ELD trial | |
Type | članek | |
Source | Clin Biochem | |
Vol. and No. | Letnik 45, št. 1-2 | |
Publication year | 2012 | |
Volume | str. 117-22 | |
Language | eng | |
Abstract | Background: We sought to investigate the effect of beta-blocker (BB) up-titration on serum levels of NT-proBNP and copeptin in patients with heart failure (HF) with reduced (HFREF) or preserved ejection fraction (HFPEF). Methods: Serial measurements of NT-proBNP and copeptin were obtained after initiation of BB up-titration in 219 elderly patients with HFREF or HFPEF. Results: After initial increasing trend of NT-proBNP at 6 weeks in HFREF patients, there was a subsequent decrease at 12 weeks of BB treatment up-titration (p=0.003), while no difference was found compared to baseline levels. In contrast to NT-proBNP, there was a continuous decreasing trend of copeptin in HFREF patients (at 12 weeks: p=0.026). In HFPEF patients, NT-proBNP significantly decreased (p=0.043) compared to copeptin after 12 weeks of BB up-titration. Conclusion: After 12 weeks of BB optimization copeptin might reflect successful up-titration faster than NT-proBNP in HFREF, while the opposite was found in patients with HFPEF. | |
Descriptors | HEART FAILURE, CONGESTIVE ADRENERGIC BETA-ANTAGONISTS NATRIURETIC HORMONE STROKE VOLUME GLOMERULAR FILTRATION RATE ROC CURVE AGED |