Author/Editor		Perše, Martina; Cerar, Anton
Title		Dextran sodium sulphate colitis mouse model: traps and tricks
Type		članek
Source		J Biomed Biotechnol
Vol. and No.		Letnik 2012
Publication year		2012
Volume		str. 1-13, 718617
Language		eng
Abstract		Inflammatory bowel disease (IBD) is a complex multifactorial disease of unknown etiology. Thus, dozens of different animal models of IBD have been developed in past decades. Animal models of IBD are valuable and indispensable tools that provide a wide range of options for investigating involvement of various factors into the pathogenesis of IBD and to evaluate different therapeutic options. However, the dextran sulphate sodium (DSS-) induced colitis model has some advantages when compared to other animal models of colitis. It is well appreciated and widely used model of inflammatory bowel disease because of its simplicity. It has many similarities to human IBD, which are mentioned in the paper. In spite of its simplicity and wide applicability, there are also traps that need to be taken into account when using DSS model. As demonstrated in the present paper, various factors may affect susceptibility to DSS-induced lesions and modify results.
Descriptors		INFLAMMATORY BOWEL DISEASES COLITIS DEXTRANS SULFATES SODIUM COMPOUNDS MICE, INBRED STRAINS DISEASE MODELS, ANIMAL