Author/Editor		Jusufović, Edin; Iljazović, Ermina; Košnik, Mitja; Keser, Dragan; Korošec, Peter; Zukić, Edin; Prnjavorac, Besim; Sejdinović, Rifat; Ajanović, Ekrem
Title		Local CD4+, CD8+ and CD56+ reactions to lung cancer in regard to pathohistological type and clinical stage
Translated title		Lokalna CD4+, CD8+ i CD56+ reakcija na karcinom pluća u zavisnosti od patohistološkog tipa i kliničkog stadija oboljenja
Type		članek
Source		Med Glas Ljek komore Zenicko-doboj kantona
Vol. and No.		Letnik 8, št. 1
Publication year		2011
Volume		str. 101-8
Language		eng
Abstract		AIM: To determinate the difference of abundance of CD4+, CD8+ and CD56+ bronchoalveolar fluid's lymphocytes and their subpopulations between non- and small cell lung cancer. Also, the differences of abundance of examined lymphocytes were compared between main clinical stages of lung cancer. METHODS: Mini-bronchoalveolar lavate was taken from lungs of 55 patients with cancer. After laboratory processing and adding CD3, CD4, CD8, CD27, CD28 and CD56 antibody, the material was analysed by flow cytometer. Results of Mini-BAL for non- and small cell lung cancer were compared, as well as the different clinical stages of the disease. RESULTS: Immature and regulatory forms of lymphocytes are more activated, while mature and activated forms are less activated in small cell lung cancer compared to non small type. With an increase of the clinical stage of disease, immunological reaction of T lymphocytes is better expressed because of increasing of abundance of immature and regulatory forms of different subpopulations of lymphocytes. CONCLUSION: All components of local CD4+ and CD8+ T lymphocyte, as well as NK and NKT cells response were more activated in lungs with small cell lung cancer, and these reactions were more expressed with an increase in the clinical stage.
Descriptors		CD4-POSITIVE T-LYMPHOCYTES CD8-POSITIVE T-LYMPHOCYTES LUNG NEOPLASMS CARCINOMA, SMALL CELL CARCINOMA, NON-SMALL-CELL LUNG LYMPHOCYTE SUBSETS ANTIGENS, CD56 BRONCHOALVEOLAR LAVAGE FLUID FLOW CYTOMETRY KILLER CELLS, NATURAL