Author/Editor		Bottalico, Danielle; Chen, Zigui; Kocjan, Boštjan J; Seme, Katja; Poljak, Mario; Burk, Robert D
Title		Characterization of human papillomavirus type 120: a novel betapapillomavirus with tropism for multiple anatomical niches
Type		članek
Source		J Gen Virol
Vol. and No.		Letnik 93, št. 8
Publication year		2012
Volume		str. 1774-9
Language		eng
Abstract		Recent studies indicate that human papillomaviruses (HPVs) from the genera Betapapillomavirus and Gammapapillomavirus are abundant in the human oral cavity. We report the cloning and characterization of a 7304 bp HPV120 genome from the oral cavity that is related most closely to HPV23 (L1 ORF, 83.7 % similarity), clustering it in the genus Betapapillomavirus (beta-PV). HPV120 contains five early and two late genes, but no E5 ORF. HPV120 was detected from heterogeneous human biological niches, including the oral cavity, eyebrow hairs, anal canal and penile, vulvar and perianal warts. Characterization of the clinical spectrum of HPV120 infections indicates a broader spectrum of epithelial tropism than appreciated previously for HPV types from the genus beta-PV.
Descriptors		PAPILLOMAVIRUS, HUMAN PHYLOGENY GENOME, VIRAL