Author/Editor		Sodja, Eva; Knez, Lea; Kern, Izidor; Ovčariček, Tanja; Sadikov, Aleksander; Čufer, Tanja
Title		Impact of ERCC1 expression on treatment outcome in small-cell lung cancer patients treated with platinum-based chemotherapy
Type		članek
Source		Eur J Cancer
Vol. and No.		Letnik 48, št. 18
Publication year		2012
Volume		str. 3378-85
Language		eng
Abstract		Introduction: The excision repair cross-complementing 1 (ERCC1) protein is an extensively investigated molecular marker because it may decrease sensitivity to platinum-based chemotherapy. Low ERCC1 expression has already been correlated with better treatment efficacy in non-small-cell lung cancer patients treated with platinum-based chemotherapy. However, the data on a prognostic and/or predictive value of ERCC1 in small-cell lung cancer (SCLC) are still very limited. Methods: This retrospective pilot study evaluated the impact of ERCC1 expression levels on response to first-line platinum-based chemotherapy with or without radiotherapy and survival outcomes of 77 SCLC patients. ERCC1 protein expression was determined immunohistochemically in primary tumour tissue. Results: ERCC1 protein expression was positive in 40/77 (51.9%) of our patients. No significant association was found between ERCC1 protein expression and response rate to first-line platinum-based chemotherapy, progression-free survival (PFS), or overall survival (OS), either in the overall population or in patients stratified by disease stage. Conclusions: In our limited group of 77 SCLC patients, ERCC1 protein expression was not found to correlate with either response rate to platinum-based chemotherapy or survival outcomes. Multi-centric prospective trials using a validated method of ERCC1 determination are mandatory in order to obtain a definitive answer on the predictive value of ERCC1 in SCLC.
Descriptors		LUNG NEOPLASMS CARCINOMA, SMALL CELL PLATINUM TUMOR MARKERS, BIOLOGICAL IMMUNOHISTOCHEMISTRY TREATMENT OUTCOME SURVIVAL ANALYSIS