Author/Editor | Dickens, Jennifer A; Miller, Bbruce E; Edwards, Lisa D; Košnik, Mitja | |
Title | COPD association and repeatability of blood biomarkers in the ECLIPSE cohort | |
Type | članek | |
Source | Respir Res | |
Vol. and No. | Letnik 12 | |
Publication year | 2011 | |
Volume | str. 1-10, 146 | |
Language | eng | |
Abstract | Background: There is a need for biomarkers to better characterise individuals with COPD and to aid with the development of therapeutic interventions. A panel of putative blood biomarkers was assessed in a subgroup of the Evaluation of COPD Longitudinally to Identify Surrogate Endpoints (ECLIPSE) cohort. Methods: Thirty-four blood biomarkers were assessed in 201 subjects with COPD, 37 ex-smoker controls with normal lung function and 37 healthy non-smokers selected from the ECLIPSE cohort. Biomarker repeatability was assessed using baseline and 3-month samples. Intergroup comparisons were made using analysis of variance, repeatability was assessed through Bland-Altman plots, and correlations between biomarkers and clinical characteristics were assessed using Spearman correlation coefficients. Results: Fifteen biomarkers were significantly different in individuals with COPD when compared to former or non-smoker controls. Some biomarkers, including tumor necrosis factor-alpha and interferon-gamma, were measurable in only a minority of subjects whilst others such as C-reactive protein showed wide variability over the 3-month replication period. Fibrinogen was the most repeatable biomarker and exhibited a weak correlation with 6-minute walk distance, exacerbation rate, BODE index and MRC dyspnoea score in COPD subjects. 33% (66/201) of the COPD subjects reported at least 1 exacerbation over the 3 month study with 18% (36/201) reporting the exacerbation within 30 days of the 3-month visit. CRP, fibrinogen interleukin-6 and surfactant protein-D were significantly elevated in those COPD subjects with exacerbations within 30 days of the 3-month visit compared with those individuals that did not exacerbate or whose exacerbations had resolved. Conclusion: Only a few of the biomarkers assessed may be useful in diagnosis or management of COPD where the diagnosis is based on airflow obstruction (GOLD). (Abs. trunc. at 2000 ch.) | |
Descriptors | ADULT AGED BIOLOGICAL MARKERS COHORT STUDIES CYTOKINES PREVALENCE REPRODUCIBILITY OF RESULTS SENSITIVITY AND SPECIFICITY UNITED STATES |