Author/Editor     Vujasinović, Miroslav; Kikec, Zdenko; Hafner, Matjaž; Ferlan-Marolt, Vera
Title     S ciprofloksacinom povzročena holestatska okvara jeter - prikaz primera
Translated title     Ciprofloxacin-induced cholestatic liver injury - a case report
Type     članek
Source     Zdrav Vestn
Vol. and No.     Letnik 81, št. 9
Publication year     2012
Volume     str. 676-80
Language     slo
Abstract     Background: Drug-induced liver injury has been described for a large number of drugs. It is a common cause of drug withdrawal from the market. Ciprofloxacin is a commonly prescribed fluoroquinolone antibiotic and is a rare cause of hepatotoxicity. To our best knowledge this is the first case of ciprofloxacin-induced cholestatic liver injury in Slovenia. Case report: A 19year old man has been treated with ciprofloxacin at a daily dose of 500 mg twice a day due to a mild respiratory infection. After twenty days he was admitted to hospital because of jaundice. Laboratory findings showed a typical pattern of acute cholestatic liver failure, which was additionally confirmed by the liver biopsy. The patient was treated symptomatically. Ten months later the patient's clinical status is stabile with a normal bilirubin level and mildly elevated alkaline phosphatase and gamma-glutamyltransferase. Conclusion: Although severe hepatotoxicity after the administration of ciprofloxacin is rare, physicians should be cautious and alert to its side-effects.
Descriptors     CIPROFLOXACIN
LIVER DISEASES
CHOLESTASIS, INTRAHEPATIC
ADULT