Author/Editor		Mirkovič, Tomislav; Kneževič, Ivan; Radan, Ivan; Rozman, Janez; Geršak, Borut; Podbregar, Matej
Title		Frequency dependent effect of selective biphasic left vagus nerve stimulation on heart rate and arterial pressure
Type		članek
Source		Signa Vitae
Vol. and No.		Letnik 7, št. 2
Publication year		2012
Volume		str. 63-8
Language		eng
Abstract		Activation of the parasympathetic pathway leads to negative chronotropic, dromotropic, and inotropic changes of heart function. The ability to selectively stimulate certain superficial compartments of peripheral nerves has been demonstrated previously. The aim of the present study was to find a clinically acceptable selective biphasic vagus nerve stimulation technique, which could allow gradual regulation of heart rate and systemic arterial pressure. In two patients, the left vagus nerve was stimulated with a combination of quasi-trapezoidal cathodic and rectangular anodic current pulses with different stimulation frequencies (10Hz, 20Hz, 30Hz) and increasing current. The heart rate and systemic arterial pressure decreased with increasing current at all different stimulation frequencies (p<0.05). The heart rate and arterial pressure response was more gradual with 10Hz compared to 20Hz/30Hz vagus nerve stimulation (p<0.05). In conclusion, selective vagus nerve stimulation, with a combination of quasi-trapezoidal cathodic and rectangular anodic current pulses at 10Hz, offers gradual heart rate and systolic arterial pressure control.
Descriptors		VAGUS NERVE ELECTRIC STIMULATION HEART RATE BLOOD PRESSURE ECHOCARDIOGRAPHY ENDARTERECTOMY, CAROTID CORONARY ARTERY BYPASS