Author/Editor		Žigon, P; Čučnik, S; Ambrožič, A; Sodin-Šemrl, S; Kveder, T; Božič, B
Title		Antibodies to phosphatidylserine/prothrombin complex as an additional diagnostic marker of APS?
Type		članek
Source		Lupus
Vol. and No.		Letnik 21, št. 7
Publication year		2012
Volume		str. 790-2
Language		eng
Abstract		Antiprothrombin antibodies can be measured by ELISA using either a prothrombin/phosphatidylserine complex (aPS/PT) or prothrombin alone (aPT) as antigen. We aimed to compare the clinical features of autoimmune patients with avidity of aPS/PT and determine the diagnostic efficiency of aPS/PT and aPT for assessing antiphospholipid syndrome (APS). aPS/PT were of low (n = 9), heterogeneous (n = 31) and high (n = 8) avidity out of 48 cases. None of the samples with low avidity were positive in aPT ELISA. Among patients with heterogeneous or high avidity aPS/PT, there was a significantly greater number of patients with APS as compared to patients with low avidity (38/39 vs. 7/9; p < 0.05). No SLE patients had high avidity antiprothrombin antibodies.
Descriptors		PROTHROMBIN ANTIBODY AFFINITY ANTIPHOSPHOLIPID SYNDROME AUTOANTIBODIES BIOLOGICAL MARKERS ENZYME-LINKED IMMUNOSORBENT ASSAY LUPUS ERYTHEMATOSUS, SYSTEMIC PHOSPHATIDYLSERINES