| Abstract | | Objective: Pregnancy is characterized by progressive insulin resistance. The present study evaluated whether the adiponectin/leptin ratio is associated with insulin resistance in pl-egnancy, since this ratio has been shown to be associated with insulin resistance in obesity, type 2 diabetes mellitus, metabolic syndrome and polycystic ovary syndrome. Methods: ln this cross-sectional study, adiponectin and leptin concentrations were measured in pregnant women using enzyme-linked immunosol-bent assays. Insulin resistance was assessed using the homeostasis model assessment of insulin resistance (HOMA-IR). Results: Mean ± SD age of the participants (n = 74) was 30.76 ± 4.27 years, mean ± SD gestational age was 26.81 ± 3.52 weeks and median body mass index (BMI) before pregnancy was 22.68 kg/m2 (interquartile range 20.75-26.79 kg/m2). There was a significant correlation between the HOMAIR and leptin concentration, but not between the HOMA-IR and adiponectin concentration. There was a significant inverse correlation between the HOMA-IR and adiponectin/leptin ratio. The adiponectin/leptin ratio was inversely correlated with BMI before pregnancy. Conclusion: The adiponection/leptin ratio inversely correlates with HOMA-IR in pregnancy.
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