Author/Editor | Gregory, Frederick D; Bryan, Keith E; Pangršič, Tina; Calin-Jageman, E; Moser, Tobias; Lee, Amy | |
Title | Harmonin inhibits presynaptic Cav1.3 Ca2+ channels in mouse inner hair cells | |
Type | članek | |
Source | Nat Neurosci | |
Vol. and No. | Letnik 14, št. 9 | |
Publication year | 2011 | |
Volume | str. 1109-11 | |
Language | eng | |
Abstract | Harmonin is a scaffolding protein that is required for normal mechanosensory function in hair cells. We found a presynaptic association of harmonin and Ca(v)1.3 Ca(2+) channels at the mouse inner hair cell synapse, which limits channel availability through a ubiquitin-dependent pathway. |