Author/Editor		Genden, Eric M; Sambur, Ian M; Almeida, John R; Strojan, primož
Title		Human papillomavirus and oropharyngeal squamous cell carcinoma ewhat the clinician should know
Type		članek
Source		Eur Arch Oto-Rhino-Laryngol
Vol. and No.		Letnik 270, št. 2
Publication year		2013
Volume		str. 406-16
Language		eng
Abstract		The incidence of oropharyngeal squamous cell carcinoma (OPSCC) is rising in contrast to the decreasing incidence of carcinomas arising in other subsites of the head and neck. The human papillomavirus (HPV) infection has played an increasing role in these epidemiological changes and as the etiology for a significant fraction of head and neck squamous cell carcinomas, OPSCC in particular. Most importantly, many retrospective studies have shown that the prognosis differs significantly between patients with HPV-associated tumors and non-HPV associated tumors. Thus, questions arise on the choices of treatment for patients based on HPV status and the consequences of therapy. Given the recognized relevance of HPV status in OPSCC, many new questions concerning the biology, treatment, and prevention of HPV infection arise. This review is intended to highlight some of the major issues and frequently asked questions relevant for the clinician dealing with patients with OPSCC.