Author/Editor		Košak, Urban; Obreza, Aleš
Title		Nikelj kot pomemben element v sledovih?
Translated title		Nickel as important trace element?
Type		članek
Vol. and No.		Letnik 63, št. 5/6
Publication year		2012
Volume		str. 297-304
ISSN		0014-8229 - Farmacevtski vestnik
Language		slv
Abstract		Nikelj je prehodni element, ki v biokemičnih procesih prehaja med stanji z oksidacijskimi števili 0, +1, +2 in +3. Ker nikelj vsebujočih encimov ali kofaktorjev, ki vsebujejo nikelj, pri ljudeh in živalih še niso odkrili, njegova vloga v teh organizmih še ni povsem znana. Pri mikroorganizmih je nikelj sestavni del osmih encimov, ki so ključni za preživetje ne zgolj mikroorganizmov, ki jih vsebujejo, ampak tudi ostalih organizmov. S farmacevtskega vidika je ureaza najbolj pomemben nikelj vsebujoči encim, ki je virulentni dejavnik pri nekaterih patoloških stanjih. Pri ljudeh v strokovni literaturi ni opisanih primerov pomanjkanja niklja, zato uživanje njegovih spojin v obliki prehranskih dopolnil nima racionalne osnove. Poleg tega so nikljeve spojine znani kožni alergeni, povzročajo fibrozo pljuč, zastrupitve ledvic in krvožilnega sistema ter so dokazano kancerogene.Nickel is a transition metal that cycles through redox states 0, +1, +2 and +3in biochemical processes. The role of nickel in humans and animals is not completely understood due to the lack of knowledge of enzymes or cofactors that include nickel. In microorganisms eight nickelcontaining enzymes are known. These enzymes are essential not only to the microorganisms but also to other organisms. From a pharmaceutical standpoint urease is the most important nickel-containing enzyme due to its role as a virulence factor in certain pathological conditions. In humans there is no case of nickel deficiency presented in professional literature, therefore the use of dietary supplements containing nickel has no rational base. Nickel compounds are known to cause skin allergies, lung fibrosis, kidney and cardiovascular system poisoning and stimulate the neoplastic transformation of cells.
Keywords		nikelj metaloencimi esencialni element toksičnost kemizem nikljevih spojin