Author/Editor     Ekart, Robert; Kovačič Grobelšek, Vesna; Dai, Klara; Černelč, Peter; Hojs, Radovan
Title     Rare manifestation of the thrombotic microangiopathy in a patient with sarcoidosis, common variable immunodeficiency and large B-cell non-hodgkin lymphoma
Type     članek
Vol. and No.     Letnik 48, št. 3
Publication year     2013
Volume     str. 345-347
ISSN     1473-0502 - Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis
Language     eng
Abstract     58-year old Caucasian woman was diagnosed with sarcoidosis. Low immunoglobulin levels were found and common variable immunodeficiency (CVID) was diagnosed 1year later. Laboratory tests and clinical course at this time revealed thrombotic microangiopathy (TMA). Therapeutic plasma exchange was started and her clinical status and laboratory parameters improved. According to CVID she received human immunoglobulin intravenously. Four months later we noticed swelling of the parotid glands and generalized lymphadenopathy. Histology of cervical lymph node confirmed large B-cell non-Hodgkin lymphoma (B-cell NHL). To the best of our knowledge, TMA complicating the course of sarcoidosis, CVID and B-cell NHL has never been reported.
Keywords     mikroangiopatija, trombotična
sarkoidoza
ne-Hodgkinsov limfom B-celic
imunska pomanjkljivost
znaki in simptomi