Author/Editor		Fleischmann, CM
Title		Tumor studies using tumor cells resistant to interferon
Translated title		Odpornost tumorskih celic za interferon
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 63, št. Suppl 2
Publication year		1994
Volume		str. II-23-II-2
Language		eng
Abstract		Background. An understanding of the contributions of the various IFN-induced antitumor effects would be beneficial for decision making regarding the clinical use of the IFN. Methods. Physiologically IFN-resistant B16 melanoma cells (B16alpha res cells) were studied in an in vivo tumor model. Results. B16 melanoma cells resistant to the in vitro antiproliferative effects of IFN were more sensitive to the in vivo antitumor effects of the same IFN. Conculsion. The B16alpha res cells are useful for the study of IFN induced host-mediated antitumor effects and appear to be significantly more immunogenic than the B16 cells.
Descriptors		MELANOMA, EXPERIMENTAL INTERFERON-ALPHA MICE ANIMALS, LABORATORY SURVIVAL RATE