Author/Editor		Kotnik, V; Čižek-Sajko, M; Ihan, A; Simčič, S; Wraber, B; Štalc, A
Title		Natural and artificial immunomodulation
Translated title		Naravna in umetna imunomodulacija
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 63, št. Suppl 2
Publication year		1994
Volume		str. II-49-II-5
Language		slo
Abstract		Background. Immunomodulation is an natural event. It is important in the development of the disease and healing. Understanding of these natural events leads to the production of natural and artificial substances useful for the therapy. Some of them carz increase, some decrease the selected immune defence activities. A lot more is known about immunosuppressants than about immunostimulators. In the presentation the authors discuss some natural and artificial immunomodulatory mechanisms to elucidate the complexity of these events, supporting their opinion with experimental data. First they discuss Il-2/soluble Il-2 receptor system, where attempt was made to present the regulatory role of soluble Il-2R molecule. Next the authors discuss the problem of target recognition by NK cells. The possible involvement of an IFN gamma-like molecule originating from the target cell is proposed to be of significance.
Descriptors		LYMPHOCYTE TRANSFORMATION INTERLEUKIN-2 RECEPTORS, INTERLEUKIN-2 KILLER CELLS, NATURAL ANTIBODIES, MONOCLONAL KILLER CELLS INTERFERONS