Author/Editor		Šmid, Lojze; Kepe, Vladimir; Vinters, Harry V.; Bresjanac, Mara
Title		Postmortem 3-D brain hemisphere cortical tau and amyloid- pathology mapping and quantification as a validation method of neuropathology imaging
Type		članek
Publication year		2013
ISSN		1387-2877 - Journal of Alzheimer's disease : JAD
Language		eng
Abstract		This work is aimed at correlating pre-mortem [18F]FDDNP positron emission tomography (PET) scan results in a patient with dementia with Lewy bodies (DLB), with cortical neuropathology distribution determined postmortem in three physical dimensions in whole brain coronal sections. Analysis of total amyloid- (A) distribution in frontal cortex and posterior cingulate gyrus confirmed its statistically significant correlation with cortical [18F]FDDNP PET binding values (distribution volume ratios, DVR) (p < 0.001, R = 0.97, R2 = 0.94). Neurofibrillary tangle (NFT) distribution correlated significantly with cortical [18F]FDDNP PET DVR in the temporal lobe (p < 0.001, R = 0.87, R2 = 0.76). Linear combination of A and NFT densities was highly predictive of [18F]FDDNP PET DVR through all analyzed regions of interest (p < 0.0001, R = 0.92, R2 = 0.85), and both densities contributed significantly to the model. Lewy bodies were present at a much lower level than either A or NFTs and did not significantly contribute to the in vivo signal. [18F]FDG PET scan results in this patient were consistent with the distinctive DLB pattern of hypometabolism. This work offers a mapping brain model applicable to all imaging probes for verification of imaging results with A and/or tau neuropathology brain distribution using immunohistochemistry, fluorescence microscopy, and autoradiography.
Keywords		amyloid brain dementia amiloid brain demenca