Author/Editor		Lledo, P-M; Johannes, L; Vernier, P; Zorec, R; Darchen, F; Vincent, J-D; Henry, J-P; Mason, WT
Title		Rab3 proteins: key players in the control of exocytosis
Type		članek
Source		Trends Neurosci
Vol. and No.		Letnik 17, št. 10
Publication year		1994
Volume		str. 426-32
Language		eng
Abstract		Although some mechanistic aspects of exocytosis, such as fusion events, have been well documented by the technique of time-resolved membrane-capacitance measurement, it was only recently that new insights into the molecular mechanisms involved in the traffic of secretory vesicles were provided by the convergence of different lines of research. In this review Lledo et al. present some of the recent findings concerning small GTPases of the Rab3 subfamily which regulate hormone release, triggered by entry of Ca2+, in endocrine and neuroendocrine cells. In view of these new results, Rab proteins might be considered as candidates for inhibition or stimulation of specific steps involved in vesicle traffic.
Descriptors		EXOCYTOSIS G-PROTEINS CELL MEMBRANE CALCIUM GTP PHOSPHOHYDROLASE EUKARYOTIC CELLS CYTOSOL