Author/Editor     Žiberna, Lovro; Jurič, Damijana Mojca
Title     Histaminski receptor tipa 3 - od gena do terapevtske tarče
Translated title     Histamine receptor type 3 - from gene to drug target
Type     članek
Vol. and No.     Letnik 52, št. 2
Publication year     2013
Volume     str. 255-270
ISSN     0353-3484 - Medicinski razgledi
Language     slv
Abstract     Histamine receptor type 3 was discovered in 1983 by Schwartz and coworkers and cloned in 1999. The expression ofhistamine receptor type 3 is largely confined to the central nervous system, where differential transcriptional and posttranscriptional processing lead to a high degree of molecular and functional heterogeneity. Histamine receptor type 3 has unique properties including constitutive activity in viva and the recruitment of plasticity-related signal transduction pathways, including Gai/0 - proteins, adenylyl cyclase, phospholipase Az, mitogen-activated protein kinase and Akt/glycogen synthase kinase 3 signalling. These make the histamine receptor type 3 the most prominent target for histaminergic drug development. Histamine receptor type 3 can function both as an auto receptor and as a heteroreceptor. As an autoreceptor on histaminergic neurons, histamine receptor type 3 activation inhibits celi firing, histamine synthesis and release. As a presynaptic heteroreceptors on other neurons, histamine receptors type 3 abundantly control the outf1ow of various neurotransmitters, including biogenic amines, acetylcholine, glutamate and y-amino butyric acid. The histamine receptor type 3 functioning is associated with cognition, behaviour, wakefulness and sleep regulation, locomotion, appetite regulation and pa in perception.
Keywords     histamine
histamine receptor type 3
intracellular signaling
histamin
histaminski receptor type 3
intracellular signaling