Author/Editor		Zupanič-Pajnič, Irena
Title		Molekularno genetska identifikacija skeletnih ostankov
Translated title		Molecular genetic identification of skeletal remains
Type		članek
Vol. and No.		Letnik 52, št. 2
Publication year		2013
Volume		str. 213-234
ISSN		0353-3484 - Medicinski razgledi
Language		slv
Abstract		330a Histamine receptor type 3 was discovered in 1983 by Schwartz and coworkers and cloned in 1999. The expression ofhistamine receptor type 3 is largely confined to the central nervous system, where differential transcriptional and posttranscriptional processing lead to a high degree of molecular and functional heterogeneity. Histamine receptor type 3 has unique properties including constitutive activity in viva and the recruitment of plasticity-related signal transduction pathways, including Gai/0 - proteins, adenylyl cyclase, phospholipase Az, mitogen-activated protein kinase and Akt/glycogen synthase kinase 3 signalling. These make the histamine receptor type 3 the most prominent target for histaminergic drug development. Histamine receptor type 3 can function both as an auto receptor and as a heteroreceptor. As an autoreceptor on histaminergic neurons, histamine receptor type 3 activation inhibits celi firing, histamine synthesis and release. As a presynaptic heteroreceptors on other neurons, histamine receptors type 3 abundantly control the outf1ow of various neurotransmitters, including biogenic amines, acetylcholine, glutamate and y-amino butyric acid. The histamine receptor type 3 functioning is associated with cognition, behaviour, wakefulness and sleep regulation, locomotion, appetite regulation and pa in perception.
Keywords		skeletal remains short tandem repeat mitochondrial DNA skeletni ostanki kratke tandemske ponovitve mitohondrijska DNA