Author/Editor		Wagner, Christian; Steffen, Patrick; Svetina, Saša
Title		Aggregation of red blood cells
Translated title		Agrégation des globules rouges
Type		članek
Vol. and No.		Letnik 14, št. 6
Publication year		2013
Volume		str. 459-469
ISSN		1631-0705 - Academie des Sciences. Comptes Rendus, Physique
Language		eng
Abstract		Red blood cells are known to form aggregates in the form of rouleaux. This aggregation process is believed to be reversible, but there is still no full understanding on the adhesion mechanism. There are at least two competing models, based either on bridging or on depletion. We review recent experimental results on the single cell level and theoretical analyses of the depletion model and of the influence of the cell shape on the adhesion strength. Another important aggregation mechanism is caused by activation of platelets. This leads to clot formation which is life-saving in the case of wound healing, but also a major cause of death in the case of a thrombus induced stroke. We review historical and recent results on the participation of red blood cells in clot formation.
Keywords		red blood cells depletion aggregation rdeča krvna telsa izčrpavanje seštevanje