| Author/Editor | Radolli, L | |
| Title | Aktivnost črevesnih disaharidaz pri otrocih z glutensko enteropatijo: korelacija s stopnjo atrofije sluznice tankega črevesa | |
| Type | monografija | |
| Place | Ljubljana | |
| Publisher | Medicinska fakulteta | |
| Publication year | 1994 | |
| Volume | str. ? | |
| Language | slo | |
| Abstract | The correlation between the degree of atrophy of the small intestinal mucosa and the activity of intestinal disaccharidases in patients suffering from celiac disease is still controversial. The purpose of the study was to confirm any correlation between intestinal disaccharidase activity and the degree of atrophy of the small intestinal mucosa in patients with celiac disease and, respectively, whether the activity of any of the intestinal disaccharidases can be a reliable indicator of the state of the mucosa of the small intestine when histologic analysis of mucosa samples is not possible or reliable. We analysed samples of small intestinal mucosa obtained by 50 peroral aspirational biopsies in 41 children treated for celiac disease at the Department of Pediatrics of General Hospital Maribor between 1991 and 1993. On each occasion 2 mucosa samples were taken: one was treated according to the standard method for preparing permanent histological material whereupon the degree of atrophy of the mucosa was determined by histological analysis, the second was processed according to the Dahlqvist method for assessment of lactase, sucrase, maltase and palatinase activity. According to our findings, the activity of all disaccharidases in severly damaged mucosa of patients with celiac disease is significantly lower than in normal mucosa. Maltase, sucrase and palatinase activity correlate with the degree of atrophy of the small intestinal mucosa, while sucrase and palatinase activity also correlate mutually. As the activity-of maltase is highest of all disaccharidases and correlates be st with the degree of atrophy of the small intestinal mucosa, it constitutes a good indicator of the statue of the mucosa. | |
| Descriptors | CELIAC DISEASE INTESTINE, SMALL DISACCHARIDASES CHILD BIOPSY, NEEDLE ATROPHY SUCRASE |