Author/Editor     Ebner, Nicole; Springer, Jochen; Kalantar-Zadeh, Kamyar; Lainščak, Mitja; Doehner, Wolfram; Anker, Stefan D.; Von Haehling, Stephan
Title     Mechanism and novel therapeutic approaches to wasting in chronic disease
Type     članek
Vol. and No.     Letnik 75, št. 3
Publication year     2013
Volume     str. 199-206
ISSN     0378-5122 - Maturitas
Language     eng
Abstract     Cachexia is a multifactorial syndrome defined by continuous loss of skeletal muscle mass - with or with-out loss of fat mass - which cannot be fully reversed by conventional nutritional support and which maylead to progressive functional impairment and increased death risk. Its pathophysiology is characterized by negative protein and energy balance driven by a variable combination of reduced food intake andabnormal metabolism. Muscle wasting is encountered in virtually all chronic disease states in particular during advanced stages of the respective illness. Several pre-clinical and clinical studies are ongoing to ameliorate this clinical problem. The mechanisms of muscle wasting and cachexia in chronic diseasessuch as cancer, chronic heart failure, chronic obstructive pulmonary disease and chronic kidney disease are described. We discuss therapeutic targets and such potential modulators as appetite stimulants, selective androgen receptor modulators, amino acids and naturally occurring peptide hormones.
Keywords     kronične bolezni
kaheksija
terapija