| Author/Editor | Abletshauser, C; Rupprecht, H | |
| Title | Self supporting polymer films crosslinked "in situ" by simultaneous spraying of component solutions. 1. Characterization and drug diffusion | |
| Type | članek | |
| Source | Farm Vestn | |
| Vol. and No. | Letnik 45, št. 4 | |
| Publication year | 1994 | |
| Volume | str. 297-309 | |
| Language | eng | |
| Abstract | Self supporting insoluble polymer films were characterized. They are produced by "in situ" crosslinking during simultaneous spraying of aqueous polymer and crosslinking agent solution. Monofilms consist of calcium-alginate, chitosanalginate, methyl cellulose-tannin, and methylhydroxypropyl cellulose (MHTC)-tannin, respectively. Mixed films consist of calcium alginate and MHPC-tannin. The influence of nature and amount of crosslinking agents and the ratio of components in mixed films on swelling, disintegration and dissolution, as well as on drug (acetaminophen) diffusion through the polymer films was evaluated in water, artificial gastric, and artificial intestinal fluid. Most promising features for drug release control show mixed films composed of calcium-alginate and MHPC-tannin. | |
| Descriptors | POLYMERS DRUG DELIVERY SYSTEMS ALGINATES METHYLCELLULOSE DIFFUSION CALCIUM TANNINS |