Author/Editor		Legan, Mateja
Title		Korelacije med kostno maso in hormonskimi dejavniki pri androgeniziranih ženskah
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		1994
Volume		str. 65
Language		slo
Abstract		The previous investigations showed that eumenorrhoeic women with adrogen excess have higher bone mineral density (BMD) than healthy controls. We wondered if higher BMD could be in connection with plasma concentrations of androgens, estrogens, insulin and insulin-like growth factor (IGF-1), having an important role in the genesis of functinal hyperandrogenism. Al1 mentioned hormones influence on bone mineral density as well, proved by in vitro and in vivo. Nineteen women, aged 18 to 35, were included in the study, all with clinical signs of hyperandrogenism (hirsutism and/or acnae and/or androgenic alopecia) and increased serum concentration of at least one of determined serum androgens. Other endocrinological diseases with androgen excess present at functional androgenisation were excluded. Body weight was ideal (+- 20 percent). Al1 patients had no hormonal pretreatment for at least 6 months. They didn't differ on the average daily calcium intake and physical activity. Two of them were amenorrhoeic, 6 were oligomenorrhoeic, the others had normal menstrual cycles. Blood for determination of hormonal concentrations was obtained in the early follicular phase in eu- and oligomenorrhoeic women, independently in amenorrhoeic patients. Plasma concentrations of free testosterone (FT), androstendione (A), dehydroepiandrosterone sulphate (DHEAS), estradiol (E2), insulin (IRI), IGF-1 and its binding protein (IGFBP-3) were determined by RIA methods. BMD of lumbar spine (L2 - L4) was measured by dual photon absorptiometry method. Data were statistically processed using univariate and mu ltivariate analysis. The positive correlation between E2 and BMD was determined (r=0.61, p=0.005), so as between IRI and BMD (correlation coefficient 0.83). Correlation between IGF-1 and BMD was not proved. Between serum concentrations of androgens and BMD no sigificant positive correlation was found, but it remains a significant negative correlation between BMD and DHEAS (r=-0.48, p=0.(trunc.)
Descriptors		HIRSUTISM BONE DENSITY ANDROSTENEDIONE ESTRADIOL PRASTERONE ADULT RADIOIMMUNOASSAY TESTOSTERONE INSULIN INSULIN-LIKE GROWTH FACTOR I