Author/Editor		Trampuš, A
Title		Vpliv nikardipina in njegovih enantiomerov na črevesno absorpcijo digoksina pri budri in vivo
Translated title		The influence of nicardipin and its enantiomers on enteral absorption of digoxin in guinea pig in vivo
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 33, št. 4
Publication year		1994
Volume		str. 139-43
Language		slo
Abstract		Simultaneous administration of digoxin and calcium channel blockers results in increased plasma levels of digoxin. One of the possible mechanisms of this interaction could be a changed enteral absorption of digoxin under the influence of calcium channel blockers. The study of possible involvement of calcium channel blockers in the enteral absorption of digoxin showed that calcium channel blockers inhibited the intestinal absorption of digoxin. In further studies this interaction was investigated in vivo in guinea pigs given racemic form of nicardipine and its negative and positive enantiomers. Minimal lethal dose of digoxin determined intraveniously 30 min after intraduodenal administration was increased in animals pretreated with either racemic form of nicardipine or negative enantiomer, but not in those given positive enentiomer of nicardipine. These results indicate that the effectiveness of nicardipine in the described interaction depends upon its optical activity.
Descriptors		DIGOXIN INTESTINAL ABSORPTION NICARDIPINE GUINEA PIGS ANIMALS, LABORATORY STEREOISOMERS