Author/Editor		Li, Xin; Strle, Klemen; Strle, Franc
Title		Tick-specific borrelial antigens appear to be upregulated in american but not European patients with lyme arthritis, a late manifestation of lyme borreliosis
Type		članek
Vol. and No.		Letnik 208, št. 6
Publication year		2013
Volume		str. 934-941
ISSN		0022-1899 - The Journal of infectious diseases
Language		eng
Abstract		Borrelia burgdorferi (Bb) sensu lato, the etiologic agent of Lyme borreliosis, adapts to distinct environments in the mammalian host and the tick vector by differential gene expression. As a result, infected mice are not exposed to and rarely make antibodies to the set of antigens that are preferentially expressed in the tick, including outer surface protein A (OspA), Borrelia iron and copper-binding protein A (BicA), and OspD. Surprisingly, however, antibodies to OspA and BicA have been noted in American patients with Lyme arthritis. Here, we examined serum samples from 210 American patients and 66 European patients with a range of early or late manifestations of Lyme borreliosis and found that only American patients with Lyme arthritis commonly had antibody responses to OspA, BicA, and OspD. This suggests that infection with American but not European Borrelia strains often leads to concerted upregulation or derepression of tick-specific spirochetal antigens in these patients.
Keywords		lyme boreliosis borrelia burgdorferi antibody response tick OspA OspD BicA