Author/Editor		Ambrožič, J; Berger, B
Title		Vpliv lipoproteina(a) na fibrinolizo in vitro
Translated title		The effect of lipoprotein(a) on fibrinolysis in vitro
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 33, št. 4
Publication year		1994
Volume		str. 145-59
Language		slo
Abstract		Lipoprotein(a) is an independent risk factor for atherosclerotic disease. Because of its structural similarity to plasminogen, lipoprotein(a) in high concentrations may inhibit fibrinolysis, thus promoting the development of atherosclerosis. Since the inhibitory effect of lipoprotein(a) on fibrinolysis was rejected by some studies and confirmed by others, we decided to investigate in vitro clot lysis in 12 subjects with elevated concentrations of lipoprotein(a) levels and in 12 subjects with normal lipoprotein(a). The groups were matched for age, sex distribution, other lipid concentrations and fibrinolitic parameters. Spontaneous euglobulin clot lysis, euglobulin lysis induced with tissue-type plasminogen activator and lysis of non-retracted and retracted plasma clots in the absence and in the presence of plasminogen activator were measured. We compared lysis of non-retracted clots incubated in normal pool plasma and of colts incubated in the subject's own plasma. In no experiment did we established a statistically significant difference between the two groups with the exception of non-retracted clot lysis at a concentration of plasminogen activator 50 ng/ml measured after two hours of incubation in normal pool plasma. The results suggested that high concentrations of plasma lipoprotein(a) have no significant influence on in vitro clot lysis.
Descriptors		LIPOPROTEINS FIBRINOLYSIS ALTEPLASE CHOLESTEROL TRIGLYCERIDES LIPOPROTEINS, HDL CHOLESTEROL LIPOPROTEINS, LDL CHOLESTEROL FIBRINOGEN PLASMINOGEN INACTIVATORS PLASMINOGEN ACTIVATOR INHIBITOR 1 ANTIPLASMIN