Author/Editor		Zupan, Janja; van't Hof, Rob J.; Vindišar, Franci; Haring, Gregor; Trebše, Rihard; Komadina, Radko; Marc, Janja
Title		Osteoarthritic versus osteoporotic bone and intra-skeletal variations in normal bone: Evaluation with ŽCT and bone histomorphometry
Type		članek
Vol. and No.		Letnik 31, št. 7
Publication year		2013
Volume		str. 1059-1066
ISSN		0736-0266 - Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Language		eng
Abstract		Several studies have shown that in contrast to osteoporosis (OP), osteoarthritis (OA) is characterized by high bone mineral density (BMD). Bone strength not only depends on mineral content as determined by dual X-ray absorptiometry (DXA), but also on bone microarchitecture. We studied intertrochanteric bone from normal controls and OA and OP patients by bone histomorphometry (BHM) and microcomputed tomography (ŽCT) as well as DXA in order to first, test the differences between OA and OP comparing both groups to healthy controls, second, to assess variations between three different skeletal sites in controls and third, to determine the level of agreement between microCT, BHM, and DXA. Analysis was performed on 115 samples from OA and OP patients, and controls. We found significant differences between OA and OP samples in structural parameters and in the osteoid fraction (p<0.05). The majority of the intra-skeletal differences were shown between lumbar spine andfemoral head samples (p<0.05). Significant agreements were found between microCT and BHM and DXA (r=0.32-0.45, p<0.05). Our findings suggest differences in intertrochanteric bone between OA and OP, the age-related intra-skeletal variations and a correlation between microscopic and macroscopic bone evaluation methods.
Keywords		osteoartritis osteporoza histomorfometrija zdravljenje osteoporoze