Author/Editor		Derganc, Jure; Antonny, Bruno; Čopič, Alenka
Title		Membrane bending
Type		članek
Publication year		2013
ISSN		0968-0004 - Trends in biochemical sciences
Language		eng
Abstract		Many cellular processes require membrane deformation, which is driven by specialized protein machinery and can often be recapitulated using pure lipid bilayers. However, biological membranes contain a large amount of embed- ded proteins. Recent research suggests that membrane- bound proteins with asymmetric distribution of mass across the bilayer can influence membrane bending in a nonspecific manner due to molecular crowding. This mechanism is physical in nature and arises from colli- sions between such mushroom-shaped proteins. It can either facilitate or impede the action of protein coats, for example COPII, during vesicle budding. We describe the physics of how molecular crowding can influence membrane bending and discuss the implications for other cellular processes, such as sorting of glycosylphospha- tidylinositol-anchored proteins (GPI-APs) and produc- tion of intraluminal vesicles.
Keywords		membrane bending proteins imbalance upogibanje membrane beljakovine neravnovesje