Author/Editor		Fajs, Luka; Resman Rus, Katarina; Avšič-Županc, Tatjana
Title		Crimean-Congo hemorrhagic fever virus nucleoprotein suppresses IFN-beta-promoter-mediated gene expression
Type		članek
Publication year		2013
ISSN		0304-8608 - Archives of virology
Language		eng
Abstract		Crimean-Congo hemorrhagic fever virus (CCHFV) is a member of the family Bunyaviridae and is a causative agent of severe hemorrhagic disease. Knowledge regarding the pathogenesis of CCHFV is limited due to the requirement for high-containment laboratories and the lack of an immunocompetent animal host. Previous studies have shown that CCHFV delays the activation of the human innate immune response, specifically, the type I interferon response. Our study results show that antagonism of the interferon-beta promoter is mediated by the nucleoprotein of CCHFV strain Hoti, while strains IbAr10200 and AP92 do not suppress the activity of the IFN-beta promoter. Our results also suggest that several viral factors may provide antagonistic action against the type I interferon response.
Keywords		hemorrhagic fever virus immune response interferon virus hemoragične mrzlice imunski odziv interferon