| Author/Editor | Korošec Jagodič, Helena; Lunder, Dušan; Jagodič, Klemen; Parežnik, Roman | |
| Title | Primer bolnika z rezistentnim alkoholnim delirijem | |
| Translated title | Resistent alcohol withdrawal | |
| Type | članek | |
| Source | In: Urgentna medicina: izbrana poglavja 2012 Ljubljana : Slovensko združenje za urgentno medicino | |
| Publication year | 2012 | |
| Volume | str. 296-298 | |
| Language | slv | |
| Abstract | Do nastanka alkoholnega delirija pride zaradi motenj v ravnovesju živčnih prenašalcev v možganih: zvišane aktivnosti ekcitatornega sistema na eni strani ter zmanjšane aktivnosti inhibitornega sistema na drugi strani. Medtem, ko pri večini bolnikov za zdravljenje alkoholnega delirija uporabljamo zlasti benzodiazepine in ostalo podporno terapijo, so opisani primeri bolnikov, ki ne odgovorijo na standardno zdravljenje (rezistentni alkoholni delirij). Predstavljamo primer bolnika z nastalim življenjsko ogrožajočim alkoholnim delirijem. 49-letni bolnik, odvisen od alkohola, je najprej zbolel s hudim glavobolom, kateremu je sledil razvoj alkoholnega delirija. Bolnik je potreboval izrazito visoke odmerke benzodiazepinov (do 450 mg midazolama dnevno) in zdravljenje v enoti intenzivne interne medicine. Razpravljamo o dodatnih možnostih zdravljenja rezistentnega alkoholnega delirija.In delirium tremens, abnormalities occur in a number of neurotransmitter systems: there is reduced inhibitory function, and increased activity of excitatory systems. While most patients with alcohol withdrawal respond to standard treatment that includes doses of benzodiazepines, nutrition and good supportive care, a subgroup may resist therapy (resistant delirium tremens). The objective of this case report is to describe a patient with life-threatening alcohol withdrawal. The patient is a 49-year-old alcohol dependent male presenting with headache and delirium tremens development later on, who ultimately required massive doses of benzodiazepines (450 mg of midazolam) and medical intensive care unit treatment. We discuss alternative treatments for alcohol withdrawal. | |
| Descriptors | Alcohol withdrawal delirium Delirij, alkoholni Therapy Zdravljenje |