Author/Editor     Petrovič, Danijel
Title     Candidate genes for proliferative diabetic retinopathy
Type     članek
Vol. and No.     Letnik 2013
Publication year     2013
ISSN     2314-6141 - BioMed research international
Language     eng
Abstract     Several candidate genes have been so far implicated in the pathogenesis of proliferative diabetic retinopathy (PDR) in subjects with type 2 diabetes. Since the principal pathogenetic mechanisms for diabetic retinopathy (DR) and PDR are different, the main pathogenetic mechanism in DR is increased vascular permeability, whereas in PDR the crucial pathogenetic mechanisms are fibrosis and neoangiogenesis. Due to that fact, different candidate genes are expected to be involved in the development of either DR or PDR. None of the candidate genes, however, can be fully and solely responsible for the development of PDR and for DR progression into PDR. Epigenetic mechanisms are expected to be involved in the pathogenesis of PDR as well. Gene polymorphisms responsible for PDR and epigenetic mechanisms responsible for PDR are reviewed in this paper.
Keywords     diabetic retinopathy
genes
pathogenetic mechanisms
diabetična retinopatija
geni
patogenetski mehanizem