Author/Editor		Anghel, Rodica; Bachmann, Alexander; Beksac, Meral; Brodowicz, Thomas; Finek, Jindřich; Komadina, Radko; Krzemieniecki, Krzysztof; Lang, Istvan; Marencak, Jozef; Moos, Roger von; Pecherstorfer, Martin; Rordorf, Tamara; Vrbanec, Damir; Zielinski, Christoph C.
Title		Expert opinion 2011 on the use of new anti-resorptive agents in the prevention of skeletal-related events in metastatic bone disease
Type		članek
Vol. and No.		Letnik 125, št. 15-16
Publication year		2013
Volume		str. 439-447
ISSN		0043-5325 - Wiener klinische Wochenschrift
Language		eng
Abstract		Bisphosphonates have been a mainstay in the treatment of cancer-related bone disease and have greatly reduced the risk of skeletal complications. More recently, clinical studies suggested additional benefits of denosumab over zoledronic acid in the prevention of skeletal related events. Similar adverse event profiles have been reported for bisphosphonates and denosumab, with infrequent occurrences of osteonecrosis of the jaw with both agents, higher incidence of renal deterioration with zoledronic acid, and higher incidence of hypocalcaemia with denosumab. Based on current evidence, the American Society of Clinical Oncology (ASCO) and National Comprehensive Cancer Network (NCCN) guidelines do not recommend one drug class over the other in patients with metastatic bone disease. Denosumab, however, may present advantages over bisphosphonates in patients suffering from chronic renal insufficiency. Further research and growing clinical experience will refine the evidence based on which decisions in daily clinical practice can be taken.
Descriptors		Diphosphonates Neoplasm metastasis Bone neoplasms