Author/Editor		Legan, Mateja
Title		Cyclooxygenase-2, p53 and glucose transporter-1 as predictors of malignancy in the development of gallbladder carcinomas
Type		članek
Vol. and No.		Letnik 10, št. 3
Publication year		2010
Volume		str. 192-196
ISSN		1512-8601 - Bosnian journal of basic medical sciences / Udruzenje basicnih mediciniskih znanosti = Association of Basic Medical Sciences
Language		eng
Abstract		Gallbladder carcinoma is the fi fth most common malignancy of the gastrointestinal tract. O e absolute characteristics of the disease are the high mortality rate due to the late discovery of a tumor and the low therapeutic possibilities except by surgical intervention. In oncology we can predict the outcome of the disease with a combination of classical standard clinico/pathological parameters (stage of the tumors, diff erentiation) and the intrinsic genetic and biochemical properties of the tumor. Such intrinzic properties of the tumors that are connected with the outcome of the disease are the denominators (markers). O e author searched extensively for the expression and infl uence of markers included in chronic infl ammation and early carcinogenesis, cell cycle regulation and tissue hypoxia: cyclooxygenase- (COX-), p gene and glucose transporter- protein (GLUT-). O e author discusses their possible role in the development as well as fi ghting this disease, if specifi c medications targeting them were available.
Keywords		gallbladder carcinoma cyclooxygenase-2 p53 glucose transporter-1