Author/Editor		Dolenc-Stražar, Zvezdana; Ferluga, Dušan; Ovčak, Zdednka; Mašera, Andrej
Title		Lektinska histokemija in ledvični karcinom
Translated title		Lectin histochemistry of renal cell carcinoma
Type		članek
Source		In: Mašera A, editor. Tumorji ledvic. 25. memorialni sestanek profesorja Janeza Plečnika z mednarodno udeležbo; 1994 dec 1-2; Ljubljana. Ljubljana: Medicinska fakulteta, Inštitut za patologijo,
Publication year		1994
Volume		str. 45-54
Language		slo
Abstract		Lectins have been used in studies of membrane glycoconjugates cytochemistry of various tumors. Eight from a battery of fluorochrome labeled lectins from E. Y. Lab., which bound selectively to different nephron segments in normal kidney, were introduced. In our present study lectin histochemistry revealed only quantitative and no qualitative differences concerning clear cell and chromophilic renal cell carcinoma irrespectively of different grades of malignancy. The results of immunohistochemistry, and a mixture of clear and chromophilic cells found in the same tumor as well, suggested the same origin of these most frequent types of renal cell carcinoma. WGA, RCA-II and MPA reacted with different intensity and extent in the tumor cells of all 10 cases of primary renal carcinoma. The reaction of tumor cells with RCA-II, the marker of the proximal tubule, and MPA, the marker of the distal tubule, was characteristic of malignant cell transformation. This part is in accordance with well established hypothesis of proximal tubular origin of the majority of renal cell carcinoma.
Descriptors		KIDNEY NEOPLASMS CARCINOMA, RENAL CELL LECTINS HISTOCYTOCHEMISTRY FLUORESCENT DYES RICIN