Author/Editor		Ferluga, D; Vodovnik, A; Gale, N; Kambič, V
Title		Vznik in razvoj karcinoma v luči spoznanj molekularne genetike
Type		članek
Source		In: Mašera A, editor. Tumorji ledvic. 25. memorialni sestanek profesorja Janeza Plečnika z mednarodno udeležbo; 1994 dec 1-2; Ljubljana. Ljubljana: Medicinska fakulteta, Inštitut za patologijo,
Publication year		1994
Volume		str. 165-83
Language		slo
Abstract		Cancer is basically the result of accumulating genetic damage. Carcinogenesis in humans is a long-term multistage process which includes initiation, promotion and progression. Initiation is characterized by mutation of genes regulating cell growth, replication, differentiation, and apoptosis. Cell proliferation implicated in promotion by epigenetic events enables fixation of genetic damage. Clonal expression of cells acquiring a selective growth advantage plays an important role in carcinogenesis. Progression primarily involves genes regulating cell adhesion molecules and production of proteases. Steadily increasing knowledge about growth factors, signal transduction pathways, and cancer genes contributes to the better understanding of carcinogenesis.
Descriptors		NEOPLASMS SIGNAL TRANSDUCTION ONCOGENES CARCINOGENS GROWTH SUBSTANCES SECOND MESSENGER SYSTEMS GENES, SUPPRESSOR, TUMOR PROTO-ONCOGENES