Author/Editor | Knez, Jure; Kranvogl, Roman; Breznik, Barbara; Vončina, Ernest; Vlaisavljević, Veljko | |
Title | Are urinary bisphenol A levels in men related to semen quality and embryo development after medically assisted reproduction? | |
Type | članek | |
Vol. and No. | Letnik 101, št. 1 | |
Publication year | 2014 | |
Volume | str. 215-221 | |
ISSN | 0015-0282 - Fertility and sterility | |
Language | eng | |
Abstract | Objective: To evaluate whether urinary bisphenol A (BPA) levels in men adversely influence semen quality and embryo development after medically assisted reproduction. Design: Prospective, cohort study. Setting: University-based tertiary care center. Patient(s): A total of 149 couples undergoing their first or second IVF or intracytoplasmic sperm injection (ICSI) procedure. Intervention(s): None. Main Outcome Measure(s): Semen quality and embryo development parameters until the blastocyst stage after the IVF or ICSI procedure. Result(s): Bisphenol A was detected in 98% (n=146) of the samples with 0.1 ng/mL limit of detection. The geometric mean BPA concentration was 1.55 ng/mL. After the adjustment for potential confounders using linear regression models, an increase of natural logarithm transformed urinary BPA concentration was associated with lower natural logarithm transformed sperm count (ß=-0.241, 95% confidence interval [CI] -0.470 to -0.012), natural logarithm transformed sperm concentration (ß=-0.219, 95% CI -0.436 to 0.003), and sperm vitality (ß=-2.660, 95% CI -4.991 to -0.329). The embryo development parameters from oocyte fertilization to the blastocyst formation stage were not affected by BPA exposure. Conclusion(s): Urinary BPA concentrations in male partners of subfertile couples may influence semen quality parameters, but do not affect embryo development up to the blastocyst stage after medically assisted reproduction. | |
Keywords | bisfenol A zarodek, razvoj sperma, kakovost moško reproduktivno zdravje asistirana reprodukcija neplodnost, zdravljenje |