Author/Editor		Arko, Darja; Dovnik, Andraž; Takač, Iztok
Title		Treatment of uterine sarcomas at the Maribor University Clinical Centre between 1996 and 2011
Translated title		Zdravljenje materničnih sarkomov v Univerzitetnem kliničnem centru Maribor v obdobju 1996-2011
Type		članek
Vol. and No.		Letnik 6, št. 2
Publication year		2013
Volume		str. 30-38
ISSN		1855-5640 - Acta medico-biotechnica : AMB
Language		eng
Abstract		Namen: Maternični sarkomi so redki maligni tumorji s slabšo prognozo od endometrijskih karcinomov. Pričujoča retrospektivna študija predstavlja pregled kliničnih in histoloških značilnosti, zdravljenja in izida zdravljenja pri bolnicah, ki smo jih zaradi materničnih sarkomov zdravili v naši ustanovi v 16letnem obdobju. Metode: V obdobju 1996-2011 smo v Univerzitetnem kliničnem centru Maribor zdravili 22 bolnic s sarkomom maternice (srednja starost 60,5 let). Podatke smo zbrali retrospektivno iz bolnišničnih in ambulantnih popisov ter iz Registra raka za Slovenijo. Vse tumorje smo klasificirali v skladu z novo FIGO klasifikacijo materničnih sarkomov. Rezultati: Večina bolnic je pred diagnozo navajala pomenopavzne krvavitve. Najpogostejši histološki podtip je bil leiomiosarkom (50 %), sledila sta mu karcinosarkom (40,9 %) in endometrijski stromalni sarkom (9,1 %). Vse bolnice smo primarno zdravili kirurško, od tega 21 z laparotomijo in eno laparoskopsko. 8 bolnic je prejemalo pooperativno radioterapijo, 4 so prejemale pooperativno kemoterapijo. Progres bolezni smo ugotovili pri 8 izmed 17 bolnic, za katere smo imeli zadostne podatke. 5-letno celokupno preživetje je bilo 44 %. Zaključek: Celokupno preživetje bolnic, zdravljenih zaradi sarkoma maternice, je v naši raziskavi relativno dobro. Zaradi majhnega števila bolnic in njihove heterogenosti bi bile za zanesljivo analizo dejavnikov, ki vplivajo na preživetje bolnic z materničnim sarkomom, potrebne večje multicentrične raziskave.Purpose: Uterine sarcomas are rare malignant tumours with a worse prognosis than endometrial carcinomas. This retrospective study was performed to determine the clinical and histologic characteristics, treatment, and outcomes in uterine sarcoma patients treated at our hospital over a 16-year period. Methods: Twenty-two patients (median age, 60.5 years) with uterine sarcomas were treated at our facility between 1996 and 2011. Information was collected from hospital and follow-up records and from the Cancer Registry of Slovenia. All tumours were classified according to the new FIGO classification for uterine sarcomas. Results: The majority of the patients presented with postmenopausal bleeding. The most common histologic subtype was leiomyosarcoma (50%), followed by carcinosarcoma (40.9%), and endometrial stromal sarcoma (9.1%). All of the patients were initially treated surgically, 21 by laparotomy and 1 laparoscopically. Eight patients were treated with postoperativeradiotherapy and 4 patients received postoperativechemotherapy. Disease progression was observed in 8 of17 patients who had sufficient followup information forthis analysis. The 5-year overall survival was 44 %.Conclusion: The overall survival of patients treated for uterine sarcomas in our study was comparatively good. Due to the small number and heterogeneity of the patients, larger multicentre trials are needed for a reliable analysis of factors influencing patient survival.
Keywords		maternica, sarkom histološke značilnosti kirurško zdravljenje dopolnilno zdravljenje celokupno preživetje