Author/Editor		Cereda, Matteo; Pozzoli, Uberto; Rot, Gregor; Juvan, Peter; Schweitzer, Anthony C.; Clark, Tyson; Ule, Jernej
Title		RNAmotifs
Type		članek
Vol. and No.		Letnik 15, št. 1
Publication year		2014
Language		eng
Abstract		RNA-binding proteins (RBPs) regulate splicing according to position-dependent principles, which can be exploited for analysis of regulatory motifs. Here we present RNAmotifs, a method that evaluates the sequence around differentially regulated alternative exons to identify clusters of short and degenerate sequences, referred to as multivalent RNA motifs. We show that diverse RBPs share basic positional principles, but differ in their propensity to enhance or repress exon inclusion. We assess exons differentially spliced between brain and heart, identifying known and new regulatory motifs, and predict the expression pattern of RBPs that bind these motifs. RNAmotifs is available at https://bitbucket.org/rogrro/rna_motifs.
Keywords		multivalent RNA motifs RNA-binding proteins alternative splicing multivalentni RNA motivi RNA-vezavni proteini alternativni prepleti